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Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]
Some of the best known examples are Wegovy and Ozempic, but there are a few other GLP-1 options on the market, such as: Zepbound Mounjaro Trulicity Rybelsus Saxenda Victosa Byetta GLP-1 drugs typically come as injections (the exception is Rybelsus, which is in pill form)
These events have been noted to involve the upregulation of the ACE2 receptor
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