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A single icv injection of rAAV-lep enhances leptin transgene expression in the hypothalamus and promptly restores euglycemia that persists along with severe insulinopenia throughout a 7-week period of observation in two monogenic diabetic models the insulin-deficient non-obese Akita mice and the hyperinsulinemic, leptin-deficient, obese ob/ob mice (Ueno et al., 2006)
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