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The risk is relatively low, but the precautions to consider are: Naltrexone Can impede liver function in people with uncontrolled liver disease Hepatoxicity in high doses (rare but possible) Cant be combined with opioid medications GLP-1 Semaglutide Animal studies showed a slight increase for medullary thyroid carcinoma (MTC) Rare but possible pancreas inflammation Increase in gallbladder inflammation and gallstones Clinician Supervision For Safety Even though both medications are considered generally safe, the points above highlight the importance of clinician supervision
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