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Implications for clinical therapy Although, overall, both insulin sensitivity and beta-cell secretion are expected to improve with lowered glucose, HOMA-IR measurements over 8 weeks cannot be used to evaluate the effectiveness of treatment for an individual

The hydrogel, when covering wound surfaces, is susceptible to damage from skin movement, which could impede wound healing and increase infection risk

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Research has revealed that GPER activation induces AKT phosphorylation, which promotes osteoblast proliferation and differentiation, indirectly supports vitamin D metabolism and contributes to skeletal integrity [112]