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Standard capsules: Poor bioavailability much of the dose is broken down in the digestive tract before absorption, meaning a large portion of the labeled dose never actually reaches circulation Effervescent tablets: Better absorption due to how the effervescent reaction affects gut pH and dissolution speed, allowing more of the compound to be absorbed before breakdown Liposomal formulations: Glutathione encased in a lipid layer that protects it through digestion, generally showing the best bioavailability among oral formats Beyond format, consistency and timeline expectations are the other major determinants of perceived effectiveness
doi: 10.1186/s40168-017-0261-y 195 MachielsKJoossensMSabinoJDe PreterVArijsIEeckhautVet al
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