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Similar content being viewed by others Introduction Glutathione S -transferases (GSTs) are a diverse family of cytosolic, mitochondrial and microsomal enzymes that are primarily involved in phase II metabolism

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Similarly, bioinformatic models using eight key ferroptosis-related gene signatures, or a six-biomarker diagnostic signature centered on TP53, have demonstrated exceptionally high diagnostic accuracy in distinguishing DKD from controls (231, 232)

Distinct from apoptosis, necrosis and autophagy, Dixon and coauthors proposed for the first time a new form of oxidation-dependent and iron-dependent cell death known as ferroptosis [19]