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Key ones include: Magnesium citrate (200-400 mg daily): Helps prevent constipation, supports sleep quality, and reduces muscle cramps B12 or methylcobalamin: GLP-1 agonists can reduce B12 absorption over time, and some compounded formulations include B12 in the compound for this reason Electrolytes: Sodium, potassium, and magnesium supplementation helps offset the dehydration risk from reduced food intake Protein powder: A practical way to maintain protein targets when appetite makes eating full meals difficult Some compounded formulations include additional ingredients like glycine , niacinamide , or glycine plus B12 combinations

This combination promotes the increase of GH by both increasing the strength of the GH release pulse and increasing the number of cells that secrete GH with the two pathways converging on the somatotroph to produce a supraphysiological GH response that neither compound achieves independently

However, you can make a permanent switch from one to the other under the guidance of your doctor or a registered health professional

If you are taking medicines with a narrow therapeutic index (such as warfarin), additional monitoring (e.g., INR) may be required when starting or adjusting Wegovy