These deficiencies are implicated in a wide array of conditions, including depression, cognitive decline, psychosis, peripheral neuropathy, and myelopathy
Third, the peptide reduces levels of cleaved caspase-3 and PARP
The active species is the cation CHN at 159.21 g/mol, and it is supplied as the iodide salt, CHIN, molecular weight 286.11 g/mol, CAS 42464-96-0
What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
