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One important metric for adverse effects of GLP-1 RA therapies (typically gastrointestinal discomfort when initiating treatment) is Cmax, which is the maximum concentration of GLP-1 RA in the serum following treatment
Semaglutide's Answer Was a Higher Dose The semaglutide arm in SURMOUNT-5 topped out at 2.4 mg, which was the highest approved weight-management dosage at the time
Flexible Dosing: The trial used a flexible dosing protocol, allowing patients to adjust their dose based on tolerability
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