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Retatrutide allodynia's acylated structure and extended half-life may contribute to sustained receptor activation, potentially increasing the risk of neurological side effects compared to shorter-acting alternatives

Pingali U, Nutalapati C, Koilagundla N, Taduri G

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The preclinical safety information for Wegovy adds: In developmental toxicity studies in rabbits and cynomolgus monkeys, increased pregnancy loss and slightly increased incidence of foetal abnormalities were observed at clinically relevant exposures. While the company is now carrying out trials to explore whether such drugs are safe for pregnant women, at present it advises that semaglutide should not be used during pregnancy as it is not known if it may affect an unborn child