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Although variations were found among the lines with different mutations, quantitative reverse transcription (qRT)PCR measurement revealed a trend for reduced snRNAs of both major and minor classes in the patient-derived cells with the exception of R521G, which increased several snRNAs of the major class, particularly U4, accompanied by reduced snRNAs in the minor class (Fig

JS also underwent intensive outpatient speech/cognitive therapy in tandem with physical/occupational therapy

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