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GLP-1 receptor agonist medications are FDA-approved for adults who meet one of the following criteria: a body mass index (BMI) of 30 or higher (classified as obesity), or a BMI of 27 or higher (overweight) combined with at least one weight-related health condition such as type 2 diabetes, high blood pressure, high cholesterol, sleep apnea, or cardiovascular disease

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Several ongoing trials, including the EVOKE and EVOKE+ studies, are examining semaglutide in people with Alzheimer's disease