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SURPASS-3 evaluated tirzepatide versus insulin degludec in patients with inadequate glycemic control despite multiple oral medications
General Recommendations for Antihyperglycemic Therapy in Type 2 Diabetes Mellitus 3 Abbreviations: A1C = hemoglobin A1c
Compounded GLP-1s are not FDA-approved, and the legal basis for compounding tirzepatide and semaglutide has shifted multiple times since 2024
This measured approach often reduces the frequency and severity of adjustment-related headaches compared to rapid-escalation protocols
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