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Absence of purging doesn't mean absence of efficacy

Hair loss is not listed as a common side effect on official prescribing information, but it has been reported by many people taking GLP-1 injections

With semaglutide, many patients notice reduced appetite, improved energy levels, and enhancements in conditions such as blood pressure and blood sugar levels, frequently within weeks

At six months, people taking bupropion were 15-20% less likely to gain a clinically significant amount of weight (5% or more of their baseline) than those taking sertraline, the most commonly prescribed antidepressant.1 Some bupropion users actually lost a small amount, about half a pound on average at six months, though this reversed to a modest 1.2-pound gain by 24 months