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When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced
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However, it should be used under the guidance of a healthcare professional, with a careful evaluation of benefits and risks on an individual basis
There is no human evidence of a reliable energy boost
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