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In summary, we have demonstrated that a single amino acid replacement of leucine-973 in the juxtamembrane region of IR to phenylalanine, which is the equivalent residue in the IGF1R, is sufficient to lead to a decrease of IRS-1/PI3K/Akt/mTORC1 signaling and an increase of Shc/Gab1/MAPK cell cycle signaling
Is citicoline effective in preventing and slowing down dementia?-a systematic review and a meta-analysis
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