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Administration methods include intramuscular (IM) and intravenous (IV) injections

Importantly, non-productive HSV-1 infections can also lead to the expression of cytokines and pro-inflammatory molecules, such as interleukin-1 (IL-1), TNF- , IL-6, IL-8, macrophage inflammatory protein 1 (MIP-1 ), chemokine (C-C motif) ligand 5 (CCL5) and chemokine CXCL10 in human microglial cells (Lokensgard et al., 2001)

Also, it was proven that light-induced circadian disruption primed a heightened pro-inflammatory TNF response to LPS challenge, while immune imbalance, with increases in pro-inflammatory M1 macrophages and reductions in regulatory T cells, suggesting compromised anti-tumor immune surveillance 133,134

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