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The FDA also agreed to change a full clinical hold for the trial to a partial clinical hold pending review and approval of the company's proposed protocol for a 6-month, Phase I study to assess the potential relevance of adverse findings observed in long-term animal studies of metadoxine in relation to human exposure, Alcobra said
Without adequate L-Carnitine levels, the body cannot efficiently oxidize fatty acids for fuel, and those fats are more likely to be stored rather than utilized
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Overstimulation of metalloproteinases (MMPs), enzymes that break down collagen and elastin
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