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Common risk factors for NAION include: Diabetes High blood pressure High cholesterol Sleep apnea Small or crowded optic nerves Smoking Cardiovascular disease Older age These risk factors are important because many patients who take GLP-1 medications may already have diabetes, obesity, sleep apnea, or vascular risk factors that can also increase NAION risk

During the initial titration phase, when patients begin at the starting dose of 2.5 mg once weekly and gradually increase to therapeutic doses, some patients report more noticeable fatigue

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If taste changes or mild injection site redness occurs, clean technique and rotating injection spots usually resolve the issue