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A study indicates that 6% to 15% of opioid-nave post-op patients became chronic opioid users after major or minor surgery, including 4% of those who underwent total hip arthroplasty and 8% of total knee arthroplasty
The loss of NCOA4 significantly abolishes ferritinophagy caused by I/R injury, thus inhibiting ferroptosis
doi: 10.1186/s12885-021-07879-5 31 BottAJPengICFanYFaubertBZhaoLLiJet al
When this ratio drops, it indicates that the cell is losing its battle against inflammatory damage, a scenario frequently observed in complex chronic illnesses
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