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It is now thought to be due to leakiness of the skin barrier, which causes it to dry out and become prone to irritation and inflammation by many environmental factors

For most people, these are mild to moderate and tend to ease over time, particularly when the dose is increased slowly and gradually, which is why both medications start low and step up over several weeks

Food & Drug Administration (FDA) has not approved glutathione for skin-whitening purposes.[4] While glutathione is widely studied for its antioxidant properties, its use for cosmetic skin lightening is considered off-label