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You are testing whether the medications, side effects, costs, adherence burden (how many pills you cumulatively have to pop each day), and long-term medicalisation are justified by the likely absolute benefit

Two useful entry points if you want to read the original work are Sikiric et al

Mechanism of TNF- modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression