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The Biology of Regain After significant weight loss through any method, the body mounts a coordinated biological response aimed at returning to its previous weight
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In the same trial, those on oral semaglutide lost an average of 4.7 kg (approximately 10 lbs) versus 3.8 kg (approximately 8 lbs) with empagliflozin from baseline to week 52 in weight
A practical office definition of a GLP-1 non-responder is: A patient who loses less than 5% of starting body weight after an adequate dose, adequate duration, good adherence, correct injection technique, and review of other causes of poor weight loss
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