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These pro-inflammatory signaling molecules sound the alarm igniting the immune response and beckoning other immune cells to join the battle
And oftentimes that is doing both estrogen and progesterone and in some cases testosterone if warranted
Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM, Feingold KR (2003) Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
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