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In studies with rats, Tirzepatide and medicines that work like Tirzepatide caused thyr oid tumors, including thyr oid cancer
Conversely, the observed rise in EGT levels in gliK 18 , deficient in gliotoxin biosynthesis, could be due to either a sensory deficiency in the cellular oxidative stress response, or a compensatory mechanism to replace the frontline antioxidant, GSH, utilised for gliotoxin biosynthesis but which cannot undergo replenishment due to GliK -glutamyl cyclotransferase deficiency
Kremers, J
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