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To make a long story short, Sema is the generic form of Wegovy, a GLP-1 type diabetic drug manufactured by pharma giant Novo Nordisk that was approved for weight loss by the FDA in 2021
It is also important to consider the pharmacokinetics of both medications, as they differ in their half-lives and peak action times
In the only trial that directly compared the two so far (REDEFINE 4), Mounjaro produced slightly more weight loss than CagriSema (25.5% vs 23.0% over 84 weeks), and CagriSema didnt meet the trials main goal
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