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The Nrf2 (nuclear factor erythroid 2-related factor 2)Keap1 (Kelch-like ECH-associated protein 1)ARE (antioxidant response element) signaling pathway is a master regulator of cellular defense against oxidative and electrophilic stress

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285,286,287 The MAPK pathway is an important pathway related to UC, 288 and its inhibition reduces inflammation by downregulating the levels of proinflammatory cytokines