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Nimbolide , a limonoid tetranortriterpenoid isolated from neem plant ( Azadirachta indica ) could upregulate the HO-1 enzyme 470
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The percentage of rotations to the right (ipsilateral to the injured hemisphere) relative to total rotations was recorded
Figure 2 It has been hypothesized by certain researchers that there is an interaction between retinal macrophages and ferroptosis, given the resemblance in the functions of the macrophages and the traits of ferroptosis ( Macrophages phagocytosis contributes considerably to the removal of ferroptotic cells, which could release a DAMP called HMGB1 to activate and recruit macrophages, alerting immune defenses ( In the context of ferroptosis, either advanced glycosylation end-product specific receptor (AGER) or Toll-like receptors (TLR) on macrophages is required for DAMPs to mediate inflammation
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