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By activating the cGMP/PKG signaling pathway, it can reversibly and locally open the tight junctions of intestinal epithelial cells, thereby enhancing drug delivery efficiency by 3.5-fold and achieving a therapeutic efficacy of 98.6% in treating CRC
A meta-analysis of these revealed a statistically non-significant reduction in IMT (Mean difference between GLP-1-based therapies and controls 0.04 [0.09, 0.01]
Forzano et al
Patients are therefore advised to drink alcohol in moderation
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