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GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)
The answer lies in gene expression
And I think a 39% risk reduction is one of the most impactful risk reductions we've ever really seen, says Kamal
How did we get here, what are payers thinking and doing about it, and how can Rx Savings Solutions help their GLP-1 coverage and cost strategies
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