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It binds to GHRH receptors on pituitary somatotroph cells, stimulating the synthesis and secretion of endogenous growth hormone in a natural pulsatile pattern (1)

In research models, this mechanism has been studied in the context of photoprotection in UV-sensitive conditions particularly erythropoietic protoporphyria (EPP), where clinical development of afamelanotide as a subcutaneous implant has resulted in regulatory approval in Europe and the United States

Lipase should not be interpreted without clinical context, liver tests cannot replace gallbladder imaging, and routine calcitonin screening has uncertain value

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