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Examples of drugs that can raise the risk of serotonin syndrome if taken with Vyvanse include: selective serotonin reuptake inhibitor (SSRI) antidepressants, such as: paroxetine (Paxil, Pexeva) sertraline (Zoloft) escitalopram (Lexapro) fluoxetine (Prozac) serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants, such as: lithium (Lithobid), a drug for bipolar disorder and depression buspirone, a drug for anxiety triptan medications for migraine, such as: almotriptan (Axert) eletriptan (Relpax) frovatriptan (Frova) naratriptan (Amerge) rizatriptan (Maxalt) sumatriptan (Imitrex) zolmitriptan (Zomig) certain pain medications, such as: other amphetamine drugs, such as: amphetamine (Evekeo, Adzenys, Dynavel) amphetamine/dextroamphetamine (Adderall, Mydayis) dextroamphetamine (Dexedrine) methamphetamine (Desoxyn) monoamine oxidase inhibitors (MAOIs), such as: phenelzine (Nardil) isocarboxazid (Marplan) If you take any of these drugs, talk with your doctor before taking Vyvanse