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Investigating the molecular mechanisms enabling TIC growth within 3D gels could unveil new targets to selectively inhibit TIC growth and prevent lymphomagenesis

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To generate Rps15 MT /Trp53 del mice, Cd19 -Cre/+ Trp53 - del fl/fl and C57BL/6 mice (JAX stock #632) were crossed to generate Cd19 -Cre/+ Trp53 - del fl/+ Rps15 +/+ mice, and Cd19 -Cre/+ Rps15- S138F fl/fl and Cd19 -Cre/+ Trp53 - del fl/fl were then further crossed to generate Cd19 Cre/+ Trp53 fl/+ Rps15- S138F fl/+ and Cd19 Cre/+ Trp53 fl/+ Rps15- S138F fl/fl ( RPS15 WT, heterozygous and homozygous) mice

Those misuse rates were comparable to those for phentermine-topiramate (Topamax), a combination weight-loss stimulant drug