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According to the FDA prescribing information, tirzepatide is not recommended for patients with severe gastrointestinal disease, such as severe gastroparesis
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Additionally, the activation of the GIP receptor by Tirzepatide stimulates the release of insulin and inhibits the production of glucagon
Their clinical utility urgently requires validation through well-designed, large-scale randomized controlled trials
Weekly monitoring during escalation: During dose increases, measure resting heart rate each morning using the same protocol
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