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A review of Phase 2 and 3 clinical trial data on oral GLP-1 receptor agonists is now informing how clinicians think about positioning these agents relative to injectables in chronic weight management practice

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In line with previous studies 7,20 , objectively dividing BMIS participants into TMAO clusters using k-means 27 revealed that those in the cluster with the highest TMAO levels had consistently worse cardiometabolic traits and were significantly older when compared to those in the cluster with lowest TMAO levels (Supplementary Fig