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Receptor binding assays on hGLP-1R overexpressing cells showed that, compared to hGLP-1 and Ex-4 both platypus and echidna GLP-1 peptides have lower affinity for the human receptor (Fig

This is consistent with the peptides role in accelerating the resurfacing and regenerative processes that normally slow with age

As the use of GLP-1 medications for weight loss continues to grow, researchers are examining how these drugs may affect other areas of our health

Human causation remains unproven, but the drug is contraindicated in people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2