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The knowledge gained from in vitro , preclinical, and animal studies has encouraged a variety of clinical trials investigating the role of dietary choline supplementation in disease progression ( Table 1 ), as well as the association between circulating choline-containing metabolites and disease prognosis or clinical symptoms ( Table 2 )
missing or taking doses late during tolerance trials creates cycles that lead to more hunger, frustration, and eventually giving up
The convergence of receptor bias, poly-agonism, and immune signaling interference defines a new era of antidiabetic drug design, aiming not only to normalize glycemia but to reprogram metabolic homeostasis at its molecular core
