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The sixth coordination site, the center of reactivity, is variable, being a cyano group (-CN), a hydroxyl group (-OH), a methyl group (-CH3) or a 5-deoxyadenosyl group (here the C5 atom of the deoxyribose forms the covalent bond with Co), respectively, to yield the four B12 forms mentioned above
In pernicious anaemia, the immune system mistakenly attacks the gastric parietal cells that produce intrinsic factor, leading to B12 deficiency over time
Compounded multi-agent topicalscombining a DHT blocker, a vasodilator, an anti-inflammatory, and an antifungal in one applicationcan address several pathways simultaneously, improving adherence by reducing the number of products a patient has to apply
Consistency protects patients during routine medication preparation steps
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