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Most gastrointestinal symptoms are mild to moderate in severity and tend to diminish over time as the body adjusts to the medication, particularly when dose escalation follows the recommended gradual titration schedule
You should first focus on treating the underlying condition under the guidance of a healthcare professional
Despite that a meta-analysis of the few studies of DS-CHD is yet not possible due to their relatively small number (Table 4), a recent meta-analysis of 18 case-control studies, that included data from 18.500 cases of CHD, revealed that maternal folic acid supplementation is associated with a significant decreased risk of CHD (OR: 0.72, 95%CI: 0.630.82), and the association remained significant even after stratification of the data into CHD subtypes (Feng et al., 2015)
However, the history of diabetes medications illustrates how clinical serendipity has been as productive as molecular modelling, logical scientific design and mass screening for active compounds [5]
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