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Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity

Similar changes have been observed in the lung which is also characterized by evidence of increased oxidative stress including glutathione depletion, a shift to alternative methods of energy production, and reduced levels of ATP 15