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Eur J Gen Pract (2006) 12(4):16973.10.1080/14017430601049449 24 Sanz-CuestaTGonzalez-EscobarPRiesgo-FuertesRGarrido-ElustondoSdel Cura-GonzalezIMartin-FernandezJet alOral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (project OB12)

Observations indicate stimulation of osteogenic processes, including increased osteoblast engagement and improved mineralized matrix formation, contributing to enhanced bone continuity and strength during regeneration

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Over time this leads to poor quality tissue repair that is susceptible to reinjury and pain