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Summary of Key Points What: B injections are vitamin B12 delivered IM/SC (usually 1000 g/mL)

In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

Treatment of progressive multiple sclerosis: What works, what does not, and what is needed

Dietary changes and supplements can still be used to meet everyday vitamin needs, but routine injections can help ensure you stay healthy