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Many patients remain insufficiently active and continue to live with overweight or obesity, while lifestyle intervention alone often fails to produce substantial and durable weight loss ( These findings raise a broader clinical question: how should anti-obesity pharmacotherapy be integrated into conservative care, rehabilitation, local symptom-relieving procedures, perioperative optimization, and arthroplasty decision-making for selected patients with obesity-related KOA
It is as much an institutional, political, and social process that determines which conditions attract research funding, clinical attention, insurance coverage, and public concern
