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The hepatocyte growth factor system and its receptor c-Met, the pathway dihexa is designed to switch on, is one of the most studied cancer pathways in all of oncology
Activity-based protein profiling, coupled with functional assays, identified the glutathione peroxidase GPX4 as a target
Further epigenetic evaluation revealed reductions in three histones (H3Ac, H4Ac, H3K4me3) that transcriptionally activate insulin-2 gene promoters and significant elevation in two histones (H3K9me3, H3K20me3) that suppress/silence these promoters [172]
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