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Studies suggested that mitochondrial haplogroups, defined by characteristic mitochondrial DNA (mtDNA) variations, represent evolutionary adaptations potentially underlying Tibetan high-altitude adaptation [13,14,15]

However, how and if predicted differences in dynamics of receptor G protein interactions correlate to the differences in the effect of the allosteric coupling of the G protein on TMD binding sites, or the rates of G protein activation are unclear and additional studies will be required to address this

Nauck MA, Ratner RE, Kapitza C, Berria R, Boldrin M, Balena R