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Accessed 29 July 2022
[19] Amidinium and phosphonium salts [edit] To avoid epimerization through the O-acylisourea intermediate formed when using a carbodiimide reagent, an amidinium- or phosphonium-reagent can be employed These reagents have two parts: an electrophilic moiety which deoxygenates the carboxylic acid ( blue ) and masked nucleophilic moiety ( red )
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Reproducibility across studies also depends heavily on peptide purity and sourcing, which is why researchers designing BPC-157 studies typically prioritize suppliers that provide third-party certificates of analysis (COAs) confirming identity and purity before a compound enters a laboratory protocol
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