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While some people notice improvements in skin hydration or sleep quality within a few weeks, the most significant structural changessuch as improved joint comfort and skin elasticitytypically take 8 to 12 weeks of daily, consistent use
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It is also worth noting the regulatory context honestly: many peptides used in performance protocols are not FDA-approved for body composition, and Tesamorelin's approval is specific to HIV-associated lipodystrophy
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