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However, a surprising discovery revealed that cellular senescence may elicit stemness, and that this mechanism plays an important role in cancer relapse [ 4 , 5 ]
Renk fights back with a multi-pronged approach that tackles the problem from every angle for the best results
Upregulation of the PD-L1/PD-1 axis induces T cell exhaustion, while the expression of dont eat me signals, such as CD47 (interacting with SIRP) and CD24 (interacting with Siglec-10), prevents macrophage-mediated phagocytosis
Tamoxifen (Sigma Aldrich, T5648) was administered by intraperitoneal injection at 160 mg/kg once daily for 5 days
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