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Subsequent cell-based work has documented elevated intracellular NAD+ and increased sirtuin pathway activity following NNMT inhibition in adipocyte cultures
These include: Metformin (used for diabetes or PCOS) Proton Pump Inhibitors (used for acid reflux or GERD) H2 Blockers Birth control pills Certain antibiotics If youre taking these medications long-term, particularly in combination, regular B12 injections might be beneficial
In aged mice, treatment with 5-amino-1mq combined with exercise produced remarkable results
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