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Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

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"And that's why we see a lot of the effects that we see." "It's important to do it the right way and really treat these drugs with respect, treat your body with respect, and understand that this is a wonderful tool if it's used the right way."

In general, dose selection for an elderly patient should start at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy